The replacement market and efficiency requirements will probably lead to two slightly overlapping types.
Boeing has mentioned it before. If you make an airframe suitable for 120-220 passengers you get a heavy unpopular one at the bottom (737-600, A318) and payload range restricted aircraft on top (B737-900 / A321).
As Carson says you probably don´t want to fight lean Embraer with their succesfull Emb 190/195 so starting at 130 seats seems reasonable. 130-180 seats seems a reasonable range. Maybe something 5 abreast like this:
http://i191.photobucket.com/albums/z160/keesje_pics/LRJ_Boeing_Embraer_Y1_narrow_bod-1.jpg?t=1197069599
Above it could be an airframe able to to 170-240 seats. A new technology 757.
Both should be able to do A320 style cargo and offer similar seat width.
BTW: I can positively confirm Airbus is not waiting what happens sitting on its hands, do a google Acare + Aircraft
Interesting IMO is Boeing & Airbus don´t want todevelop anything new. The airlines are increasingly pushing them and the engines OEMs.
No airline wants to be the last one to order a moderate efficient fleet of 737s, getting them in 4 years and being stuck with them until 2031..