Cameroon Airlines was the national airline of Cameroon based in Douala, operating scheduled services within Africa and to Europe and the Middle East.

Established in July 1971 it started operations in November of the same year with two Boeing 737-200 aircraft between Douala and Yaoundé. A service was started to Rome and Paris using an ex-Air France Boeing 707, replaced by a Boeing 747-200 in 1982.

In September, 2005, the French civil aviation authorities banned flights to France by Cameroon Airlines for an indefinite period, citing safety concerns.

In 2006, the Cameroon government reached an agreement with SN Airholding, the parent company of SN Brussels Airlines, to revive the airline. This agreement never came to fruition and revenue losing operations continued until services came to a halt, with the airline ceasing flight operations in March 2008.