Mexican carrier Aeromar will launch non-stop service between Mexico City and Austin from 21 October.
The airline will operate on the route five-times per week, using 50-seat Bombardier CRJ200 aircraft, says the Austin city government.
"Aeromar is very pleased to expand its presence in the great state of Texas with the addition of Austin to our growing route network," says Fabricio Cojuc, Aeromar's executive vice president, chief planning and commercial officer.
Aeromar launched service to the USA with flights between Mexico City and McAllen, Texas, on 15 March.
The airline will be the only carrier operating non-stop between the two cities, schedules in Innovata show.