Aeromexico will launch service between Morelia and Chicago on 7 June.
The SkyTeam carrier will operate weekly on the route, providing competition to low-cost carrier Volaris which operates five times weekly between the two cities.
Aeromexico will also boost the frequency of flights on its routes from San Francisco to Morelia, and to Leon. It will operate thrice weekly to Morelia and twice weekly to Leon from 7 April.
The airline will operate Boeing 737 aircraft on all the flights.