Alaska Airlines will fly thrice weekly between Bellingham, Washington and Las Vegas starting 25 June, competing with leisure carrier Allegiant Air.
Boeing 737-700 aircraft will be used on Alaska's newest route, seating 112 passengers in the main cabin and 12 in first class.
Allegiant operates Boeing MD-80 aircraft on the route with 18 flights per week, according to Innovata.
Seattle-based Alaska and its affiliate Horizon Air will also continue to offer four-times-daily Bellingham-Las Vegas service via Seattle.
The new city pair comes as Alaska aims to reduce mainline capacity by 8% this year.
Separately, Alaska has asked regulators for approval to codeshare with Fiji-based Air Pacific. Air Pacific will place its code on Alaska flights between Los Angeles and Vancouver shortly after approval is obtained from DOT.