Las Vegas-based Allegiant Air will discontinue operations to Long Beach effective 3 November.
The airline is operating between Long Beach and Bellingham, Idaho Falls and Las Vegas, schedules in Innovata show. With its departure, three air carrier slots have become available, said the city of Long Beach, which attributed Allegiant's withdrawal to "a shift in business direction".
"Allegiant has enjoyed high passenger load factors from Long Beach, but will be serving other markets with their fleet of [Boeing] MD-80s," said the city.
Airport director Mario Rodriguez said: "With the availability of these slots, we will be able to provide more choices and service to new cities with a focus on superior customer service."
The city said "several airlines" have expressed interest in operating to the airport, which has a total of 41 air carrier slots currently.