Regional operator American Eagle will challenge United Airlines when it launches weekend operations between Chicago and Pensacola, Florida on 12 June.
American Eagle will place 50-seat Embraer ERJ-145 jets on the forthcoming Saturday and Sunday service.
Presently ExpressJet Airlines flies between Chicago and Pensacola twice weekly on behalf of United.
After starting service to Pensacola Gulf Coast Regional airport, American Eagle will begin twice daily ERJ-140 links from Dallas to Cheyenne, Wyoming on 15 July.
No carrier currently connects Dallas with Cheyenne Regional airport, which only has service to Denver operated by Great Lakes Airlines.
American Eagle's latest routes come as the carrier has recently announced a slew of new destinations from Chicago. Flights to Sioux Falls in South Dakota, Fargo, North Dakota, Charleston, West Virginia and Harrisburg, Pennsylvania begin in April.
The carrier's new flights from O'Hare to Allentown and Wilkes-Barre, Pennsylvania start in June, followed by Blountville, Tennessee in July.