American Airlines will launch flights between Los Angeles and both Eugene and Redmond, Oregon, from 12 June.
SkyWest Airlines will operate the flights twice daily flights to Eugene and once daily flight to Redmond as American Eagle on a 50-seat Bombardier CRJ200.
"We're delighted to provide service from Redmond and Eugene to our hub in Los Angeles," says Charles Schubert, vice-president of network planning at American. "This schedule will give customers seamless access to Los Angeles and allow them to connect through this key international gateway to destinations throughout the American Airlines and Oneworld global network."
American previously served Eugene from 1985 to 1993.
The Redmond airport will help subsidise the service with the proceeds of a $500,000 grant from the US Department of Transportation Small Community Air Service Development Program, as well as support from the Central Oregon Air Service Team, which includes representatives from the city of Redmond, the Redmond Chamber of Commerce and the Central Oregon Visitors Association.
American also received revenue guarantees from the city of Redmond and airport.
Allegiant Air flies between Los Angeles and Eugene, while no carriers fly between Los Angeles and Redmond, according to Innovata schedules.