If the weather cooperates, Boeing will fly its second 787 test aircraft for the first time on 22 December.
Takeoff from Paine Field at the company's Everett, Washington facility is expected around 1645 GMT (845 local).
The aircraft will be ferried from Paine Field to Boeing's flight test operations centre at Boeing Field in Seattle.
At the controls of the aircraft, dubbed ZA002, will be Captain Randy Neville and chief project pilot Captain Mike Carriker, who flew ZA001 on its maiden flight on 15 December.
This second flight will see Neville flying the aircraft in the left seat, while Carriker will assume the right seat, the reverse of first flight.
Boeing expects to deliver the first 787 to Japan's All Nippon Airways in the fourth quarter of 2010, following nine to twelve months of flight testing.
While the aircraft is painted in ANA colors as an nod to the aircraft's launch customer, Boeing reassigned the aircraft on 27 August as part of a $2.5B research and development expense following extensive rework and modification over previous two years years.
ZA002, powered by Rolls-Royce Trent 1000 engines, is the second of six test aircraft that will participate in the certification campaign.