Luxembourg-based freight operator Cargolux is adding the Brazilian city of Manaus to its network.
It will begin operating to the destination on 19 May through a service conducted via Sao Paulo.
Cargolux says the flight continues onward from Manaus to Quito and Bogota before returning to Luxembourg via Maastricht.
"Brazil is an important market for Cargolux, it is the economic engine of the region,' says Cargolux chief Frank Reimen.
"The presence of multinational companies has stimulated demand for fast and reliable air cargo transport."