China Southern Airlines launched a twice weekly Shanghai Pudong-Zhengzhou-Chicago freighter service on 10 April.
This comes after it launched a Guangzhou-Zhengzhou-Los Angeles freighter service on 5 March, says the SkyTeam alliance member.
The carrier is using the Boeing 747 Freighter on services to Chicago, and the Boeing 777 Freighter to Los Angeles.
Innovata schedules show that China Southern is the only operator of freighter services from Zhengzhou to Chicago and Los Angeles.
Zhengzhou is the provincial capital of Henan province.