Comair chief executive Gidon Novick has resigned and his co-chief executive, Erik Venter, has assumed sole charge of the South African airline.
The carrier said that the developments arose following a decision by the board of directors that it would be best served by "single and focused leadership".
Venter said: "Agility is key to remaining competitive in an industry influenced by a weak economy and consumer spend, high oil prices, excessive airport charges and a weakening local currency."
For the past five-and-a-half years Venter and Novick served as joint chief executives of Comair Limited. Venter joined Comair as financial manager in 1996 and has held various positions since then, including commercial manager, commercial director and financial director. He was appointed joint chief executive on 1 July 2006.
Novick, who also resigned as a director of the Comair board, will retain a consulting role as well as pursuing other entrepreneurial business ventures.