Panama's Copa Airlines cancelled about 100 flights over the weekend after a glitch with its IT systems.
The Star Alliance carrier says an "interruption of the technological network" began on 19 October, which led to the cancellation of 100 flights on 19 and 20 October.
The flights represent about 16% of the carrier's operations on both days, it adds.
"These cancellations have impacted flights originating in 18 countries, affecting mainly Panama, with a mixture of local passengers as well as those connecting," says Copa.
The airline says it accommodated more than 2,000 passengers at hotels in Panama City due to the disruptions and has handled 2,500 passengers whose flights were affected.
Copa says it expects operations to return to normal today.