Delta Air Lines will end nonstop flights between Seattle and Osaka Kansai from 3 November.
An "unstable revenue environment caused by [Japanese] yen devaluation and weak demand" prompted the decision, says the Atlanta-based SkyTeam alliance member. It will continue to fly from Seattle to Tokyo, and from Osaka to both Guam and Honolulu, it adds.
The last Seattle-Osaka flight will depart 2 November and the last return flight on 3 November.
The move comes after Delta executives said that the carrier would "rationalise" capacity to Japan in the fourth quarter, following a $60 million hit to profit from the recent weakening of the yen during the second quarter.
The airline has expanded its international operations from Seattle during the past year. It added new nonstop to Tokyo Haneda and Shanghai Pudong in June, and plans to add London Heathrow flights in conjunction with Virgin Atlantic Airways from 29 March 2014.