Delta Air Lines will cut 21 flights from its schedule in Memphis from 3 January 2013, reducing the number of flights at the hub to fewer than a hundred.
Service to Birmingham (Alabama) and Jacksonville will be cancelled while frequency will be reduced to Jackson, Kansas City, Knoxville, Little Rock, Nashville, Raleigh-Durham, St. Louis and Tulsa, says the Atlanta-based carrier.
The cuts will bring scheduled weekday departures at Memphis to 94 from 115, the lowest since Delta acquired the hub when it merged with Northwest Airlines in 2008.
Delta has been steadily drawing down flights at Memphis, which serves a similar geographic region to its large Atlanta hub, for more than a year.
The airline ended service between the city and Amsterdam - Memphis' only flight to Europe - this past September.
Delta's hub in Memphis dates back to at least the 1970s when Southern Airways established a large operation at the airport, which was maintained through various mergers by Republic Airlines and later Northwest.