Delta Air Lines will launch nonstop flights between Philadelphia and Raleigh-Durham from 4 September.
The Atlanta-based SkyTeam alliance member will offer four daily flights on a 50-seat Bombardier CRJ200 operated by one of its regional partners, it confirms.
Delta will compete with US Airways on the route, Innovata schedules show.
The new Philadelphia flight will boost Delta's burgeoning focus city at Raleigh-Durham International airport, where it has grown to about 57 peak day flights this month. The carrier has grown at the airport since American Airlines began drawing down their focus city in Raleigh-Durham in 2008.
Delta was the second largest airline with a 13.9% market share at Raleigh-Durham during the year ending in February 2013, according to US Department of Transportation (DOT) data. Southwest Airlines was the largest airline with a 22.2% share.