Fuel prices and demand shifts have prompted Delta Air Lines to suspend two routes between London and the US after 16 April.
The Atlanta-based carrier will drop service between Miami and London Heathrow airport, ceding the route to American Airlines.
Delta also is cancelling the only route connecting Atlanta and London Gatwick.
The carrier confirms the decision was made "due to persistently high jet fuel prices and fluctuations in passenger demand for flights to Europe".
Delta still operates nine daily flights to Heathrow in the third quarter this year, including service from Atlanta, Boston, Detroit, New York John F. Kennedy and Minneapolis-St. Paul.