EasyJet will launch flights from Manchester airport to Moscow Domodedovo airport in spring 2013, after basing an eighth aircraft at the northern UK gateway.
The new four times weekly Moscow service will come alongside the addition of Prague and Thessaloniki to the low-cost carrier's Manchester network.
"A direct link from the north of England has been long overdue," says EasyJet chief executive Carolyn McCall. "With our strong European network we look forward to connecting Moscow with other European cities."
Ken O'Toole, chief commercial officer at Manchester Airports Group, adds that he is optimistic of "continued growth" at the airport by EasyJet, which plans to operate 32 routes from the northern base in summer 2013.
EasyJet's new Prague service will be three times weekly, while its Thessaloniki link will be twice weekly.
The airline also last month received approval to operate twice daily flights from London Gatwick airport to Moscow Domodedovo airport, becoming one of just four carriers permitted to fly between the two capital cities under existing bilateral agreements.