Fastjet will launch its first international route on 18 October after it was postponed by almost a month by administrative delays.
The pan-African low-cost carrier will initially operate three times a week between Dar es Salaam and Johannesburg, and will look to increase frequencies "as consumer demand dictates".
Fastjet had been due to start services between the Tanzanian and South African cities on 27 September. However, it delayed this citing South African authorities' last-minute demand for additional documentation.
"The South African department of transport has completed its review of the additional documents it requested and has issued an updated foreign-operator permit," says the airline's chief executive Ed Winter. "Fastjet is delighted that, in line with our expansion strategy, operations can now commence on this route."