UK regional carrier Flybe in May will launch service from Manston Airport in Kent to Belfast City, but will drop flights between Manston and Manchester.
The carrier will operate three flights a week on the route from 26 May.
Flybe will suspend all flights from Manston to Manchester on 4 April. The carrier says that "passenger numbers made the flight economically and environmentally hard to justify".
According to the schedules in Innovata, no other airline operates nonstop service on the Manston-Belfast route.