Frontier Airlines will add New Castle Airport in Delaware to its route map with flights to five cities starting in July.
The Denver-based airline says it will offer three flights weekly to both Chicago-Midway and Houston starting 1 July.
On 2 July, Frontier will begin offering two flights weekly to Orlando and four flights weekly to Frontier's Denver hub.
The airline will start two weekly flights to Tampa in Florida on 4 July.
The flights will operate on Frontier's 168-seat Airbus A320 aircraft.
New Castle Airport, which is about six miles (10km) from Delaware's largest city of Wilmington and 30 miles south of Philadelphia, currently has no commercial service. In the past it had service by Delta Air Lines and now-defunct Skybus Airlines.
The expansion comes one week after Frontier launched service to five cities from Trenton in New Jersey, which is about 30 miles north of Philadelphia. Those cities were Atlanta, Chicago-Midway, Columbus in Ohio, Detroit and Raleigh-Durham in North Carolina.
Frontier, which now serves 10 destinations from Trenton, has reduced flying in its Denver hub in the last year as it shifted capacity to secondary markets, many of them in the eastern USA.