Frontier Airlines plans to resume flights between Pittsburgh and Milwaukee from 17 May.
The carrier will operate twice weekly on the route. It withdrew the flight in January 2011.
"Frontier Airlines is pleased to bring Pittsburgh travellers their only nonstop access to Milwaukee's General Mitchell International airport," said Daniel Shurz, Frontier's senior vice president, commercial. "Customers will enjoy Frontier's low fares into Milwaukee and on connections to destinations across the United States and Mexico."
The resumption of Pittsburgh-Milwaukee comes after Frontier said earlier this week that it would cut 10 routes from Milwaukee and Kansas City in April.
From 1 April, it will drop Milwaukee-Newark from its network. This will be followed by the withdrawal of Milwaukee-Dallas/Fort Worth, Milwaukee-Grand Rapids, Milwaukee-Kansas City, Milwaukee-Philadelphia, Milwaukee-Phoenix, Kansas City-Houston, Kansas City-Los Angeles, Kansas City-San Francisco and Kansas City-Seattle from 16 April.