Middle Eastern carrier Gulf Air is to axe its service to the Syrian capital, Damascus, as well as flights to three other destinations owing to their lack of profitability.
Bahrain-based Gulf Air is stopping its operations to Athens, Milan and Kuala Lumpur as part of the network review.
Services to Damascus will be dropped from 2 March while flights to Athens and Milan will be cut on 12 March. The Kuala Lumpur service will stop on 25 March.
Gulf Air opted to close its Entebbe and Geneva routes earlier this month. The airline said it sought to address "economic challenges" including political issues - notably the chaos in Syria - plus the cost of fuel and poor passenger demand.
"The decision has been taken to allow the airline to use its fleet and resources in the most efficient way by concentrating on high-demand, high-yield routes to ensure that its core customer base is served effectively," said the carrier.