Mexican low-cost carrier Interjet will begin flights between Toluca and Las Vegas from 15 November, adding the fifth US destination to its network.
The carrier, which operates Airbus A320 aircraft, will operate twice weekly on the route.
Interjet already operates to San Antonio, Miami, New York and Orange County in the USA.
The airline will be the only carrier operating non-stop between Las Vegas and the Licenciado Adolfo Lopez Mateos International Airport in Toluca, which mostly serves as a low-cost carrier airport for Mexico City.
Two airlines operate non-stop between Mexico City Benito Juarez International Airport and Las Vegas, schedules in Innovata show. Aeromexico flies 13 times weekly non-stop on the route, while Mexican low-cost carrier Volaris operates 12 times weekly.
US Airways offers one-stop service between Mexico City and Las Vegas, and Aeromexico also operates one-stop service twice weekly on the route.