Members of the US National Transportation Safety Board (NTSB) have been dispatched to Dubai to investigate the crash of a Boeing 747-400 operated by cargo carrier UPS.
Two crew members were on board, and local media reports indicate their bodies have been recovered, quoting a statement from the UAE's civil aviation authority.
The aircraft crashed shortly after takeoff en route to Cologne, Germany, and UPS has not confirmed reports of a cockpit fire.
Flightglobal's ACAS database shows that the aircraft, 571UP, was built in 2007.
NTSB's team includes safety investigator Bill English and specialists in fire, operations and human performance. The team also includes members from GE, Boeing, UPS and the Independent Pilots Association.
Preliminary reports are indicating the aircraft crashed near a main road in Dubai.