Philippine Airlines (PAL) will launch a five times weekly service from Manila to London Heathrow from 4 November.
The service will be operated by Boeing 777-300ERs, and will operate from Terminal 4 at Heathrow.
The announcement comes after the EU exempted PAL from a blanket ban on Philippine aircraft operating in European airspace in July. PAL last served Europe in 1998, and the ban was imposed in 2010.
"That we have been given permission to fly to Heathrow makes our return much more meaningful," says chief operating officer Ramon Ang. “We take this as a strong vote of confidence by UK authorities in PAL's ability to bring in the passenger traffic volume worthy of the world's top airlines.”
Innovata schedules show that there are no other carriers flying between London and Manila.
PAL has also previously indicated that it also plans to launch services to other European destinations including Paris, Frankfurt, Amsterdam, Rome and Madrid.