Qatar Airways is to begin a five-times-weekly cargo service from Doha to London Stansted on 2 May.
The Qatari flag carrier will operate a dedicated Boeing 777 freighter on the route.
The move follows British Airways terminating a wet-leasing contract with Stansted-based Global Supply Systems (GSS) and the UK airline's parent IAG striking a capacity-purchase deal with Qatar, a partner within Oneworld.
For BA, GSS has been operating three Boeing 747-8 freighters leased from its parent Atlas Air. The arrangement, originally set to run until 2016, will now end in April.
IAG Cargo's long-term commercial agreement to purchase capacity on Qatar Airways-operated freighters is effective May. It commits the Doha-based carrier to operating five 777F flights a week between Hong Kong and London on behalf of IAG.
Qatar is also set to resume twice-weekly services to the Spanish city of Zaragoza in March, and launch a twice-weekly service to Hyderabad in India the following month, using Airbus A330 freighters for both services.
Three new freighters are to be delivered to the carrier this year: two 777s and one A330 freighter.