Irish budget carrier is continuing a programme of rapid expansion in continental Europe with another Iberian base, at Faro in Portugal.
The carrier has already disclosed today the creation of a new base at Malaga in Spain.
It has followed this with plans to open 14 new routes from Faro, and base three Boeing 737-800s at the airport, from March next year.
Ryanair will take its network from Faro to 28 destinations, with new services to Billund, Birmingham, Derry, Eindhoven, Kerry, Knock, Madrid, Marseille, Maastricht, Milan Bergamo, Oslo Rygge, Paris Beauvais and Stockholm Skavsta.
Portuguese airports operator ANA's chief, Guilhermino Rodrigues, says the decision will "help create much-needed jobs".
Ryanair's decision will give it a total of 39 bases in Europe. It already has a Portuguese base at Porto.