Ryanair plans to suspend its flights between London Stansted and Lübeck in northern Germany during the winter schedule from November until March.
The Irish carrier budget cited high oil prices and the introduction of air passenger duties by both Germany and the UK for the decision.
The company added that it is planning to resume flights on the route again for the summer 2012 schedule.
Lübeck airport said that, while the loss of the Stansted flights is a setback, it would not jeopardise its long-term existence. The airport operator is currently working on a future concept aiming for a mix of airlines and destinations, and to be less dependent on a single large customer, the company added.
Ryanair currently serves four other destinations from the airport in addition to Stansted - Bergamo (Milan), Pisa, Palma de Mallorca and Stockholm Skavsta. However, only the route to the Swedish capital will be operated during the winter schedule.
The airline said it had no plans for further route cuts at Lübeck.