Southwest Airlines will cease operations at Branson, Missouri; Key West, Florida and Jackson, Mississippi from 7 June 2014.
"Unfortunately, the level of local demand no longer allows Southwest to profitably serve these markets," says Bob Jordan, Southwest's executive vice president and chief commercial officer.
Southwest has served Jackson since 1997, and added Branson and Key West in 2012 as it integrated with its subsidiary AirTran Airways.
The Dallas-based carrier operates non-stop to Chicago, Houston and Orlando from Jackson, and flies non-stop to Dallas, Houston and Chicago from Branson. It serves Tampa, Orlando and New Orleans from Key West.
US mainline carriers United Airlines, Delta Air Lines, US Airways and American Airlines serve both Jackson and Key West. Silver Airways and Cape Air also operate to Key West. Southwest's departure from Branson will leave Frontier Airlines as the airport's only scheduled carrier.