Transaero has signed a memorandum of understanding with Moscow Vnukovo that will see the Russian carrier launch operations from the airport in May and build a maintenance facility for its aircraft.
Under the deal, Transaero will begin domestic and international services from Vnukovo in May with the aim of handling up to 2 million passengers a year at the airport.
Transaero, which has a base at Moscow Domodedovo, said last month that it was looking at moving into Vnukovo and Moscow's third airport, Sheremetyevo, in order to accommodate its planned long-haul expansion.
As part of the agreement, Transaero says Vnukovo will "guarantee the priority to the carrier's large and extra-large aircraft including Airbus A380s, Boeing 747s and Boeing 777s at all the stages of service on the ground and at the airside of the airport".
The airport and the airline have agreed to build a new maintenance hangar for A380 and 747-8 Intercontinental aircraft. In addition, the airport will assign two bays at its hangar for maintenance work on all other aircraft types in Transaero's fleet.
The two sides also plan to build a training centre featuring four full-flight simulators.
The agreement, which is valid for 10 years, will see Transaero and Vnukovo cooperate on a number of other measures aimed at developing the airport as a hub.
"We have signed a very important agreement which opens new prospects for the development of our airline in Moscow," says Transaero general director Olga Pleshakova.