United Airlines will launch daily nonstop service from Cleveland to Nashville and Oklahoma City.
Nashville flights will operate twice-daily from 19 December while Oklahoma City flights will operate daily from 14 February 2013.
Service to both cities will be operated by ExpressJet as United Express with 50-seat regional jets.
In addition, United will discontinue service between Cleveland and Green Bay from 18 December.
According to Innovata schedules, Southwest Airlines operates nonstop flights between Cleveland and Nashville. There is no service between Cleveland and Oklahoma City.