US Airways will shift its daily flight between Charlotte and London to Heathrow airport from Gatwick in March 2013.
The Tempe, Arizona-based Star Alliance carrier was awarded the slot pair at Heathrow from the European Commission, it says. The pair was one of four divested by Oneworld alliance members American Airlines, British Airways and Iberia as a condition to their receiving antitrust authority across the north Atlantic in 2010.
The flight will be operated on a 296-seat Airbus A330-300.
"This new service will augment our existing trans-Atlantic network and provide more choices for customers in markets up and down the east coast," says Doug Parker, chief executive of US Airways, in a statement.
US Airways says that it has not made a decision on whether to continue to serve Gatwick.
The airline also flies to Heathrow from Philadelphia.
No other carriers fly between Charlotte and London, according to Innovata schedules.