Spanish-linked start-up carrier Volotea will initially operate flights to 14 destinations when it launches services from Venice Marco Polo Airport on 5 April.
The carrier - which was established by Spanish low-cost carrier Vueling's founders Carlos Muñoz and Lazaro Ros - will offer five domestic Italian services to Brindisi, Cagliari, Olbia, Palermo and Reggio Calabria.
It will also operate nine international routes to Alicante, Bilbao, Malaga and Santiago de Compostela in Spain, Bordeaux in France, Hungarian capital Budapest, Krakow in Poland, Porto in Portugal and Thessaloniki in Greece.
Volotea plans to increase the number of routes it serves from Venice to 24 during the summer season.
None of the nine international routes are currently operated by other airlines. However, Ryanair serves Brindisi, Cagliari and Palermo from Venice Treviso Airport, according to Innovata schedules.