Virgin Atlantic is to open services to Ghana this year, with a link to the capital city Accra.
The UK long-haul airline will operate thrice-weekly from London Heathrow.
Services on the route will begin on 24 May, although the carrier states that the plan is still subject to governmental approval.
Virgin Atlantic will use 240-seat Airbus A340-300s whose configuration will include 34 first-class and 35 premium-economy seats.
British Airways also operates a link between Heathrow and Accra, while Ghana International Airlines serves Accra from London Gatwick.
Virgin Atlantic intends to schedule the service to provide a transatlantic connection option to Newark.