Middle Eastern carrier Emirates is cancelling its order for 70 A350s, comprising 50 A350-900s and 20 A350-1000s.
Airbus has confirmed the cancellation.
It says the decision follows talks with the Dubai-based airline over its fleet requirement, following the carrier's order for 50 A380s placed during the Dubai air show last year.
Emirates had been due to take the A350s from 2019.
"Airbus and Emirates Airline benefit from a long-standing relationship and the airline recently reiterated its confidence in Airbus products particularly by praising the A380 and the benefits the aircraft brings to their operations," says the airframer.
Emirates' decision leaves the A350 order book at 742 aircraft.