New York-based JetBlue Airways will add Antigua to its network from 5 November.
The airline will operate from New York John F Kennedy thrice weekly. In addition, it will start seasonal weekly service between Boston Logan and Barbados from 7 November.
Both routes are subject to governmental approval.
"We offer customers more flights to the Caribbean than any other airline, and the beautiful destination of Antigua will be a great addition to our network for those wanting to discover something new," says the airline's vice-president of network planning Dave Clark.
The carrier says Antigua is one of the largest Caribbean markets that it currently does not serve.
The airline flies to Barbados daily from New York JFK. The seasonal flight from Boston will be the fifth such service to Latin America and the Caribbean from the city in Massachusetts that the airline has launched in the recent year.
JetBlue will operate Airbus A320s on both routes.
It will compete against American Airlines on New York JFK-Antigua, schedules in Innovata show. JetBlue will be the only carrier serving nonstop between Boston and Barbados.
Source: Cirium Dashboard