Air Italy will stop flying to Los Angeles, San Francisco and Toronto this winter in favour of serving what it terms "counter-seasonal" destinations: the Maldives, Mombasa, Tenerife and Zanzibar.
The carrier will continue to operate its transatlantic services to Miami and New York from Milan Malpensa.
A service to Bangkok has already been axed. Air Italy's last flight to the Thai capital was conducted on 30 March.
The airline's new business-class product was rolled out on the Milan-LA route at launch earlier this year. The offering is to be made available on flights to the Maldives, Miami, Mombasa, New York, Sharm el-Sheikh and Zanzibar.
Air Italy is planning to base a number of aircraft at overnight "outstations" in Cagliari, Catania, Lamezia Terme, Naples, Palermo and Rome this winter, in order to facilitate "optimised" daily frequencies between those cities and Malpensa.
The airline, which is 49% owned by Qatar Airways, is also tweaking its schedules in order to offer 112 domestic flights a week during the winter.
"Repositioning our aircraft to the outstations overnight, we will now be able to offer enhanced connectivity to our international destinations and better timings for those coming to Milan for business or leisure," states Air Italy chief operating officer Rossen Dimitrov.