Norwegian will launch services from London Gatwick to Singapore on 28 September.
The long-haul low-cost operator will operate four-times weekly on the route, rising to to five-times weekly during the northern winter season between October and March.
The services, operated by its UK subsidiary, will use Boeing 787-9s configured with 344 seats in two classes, says Changi Airport Group in a statement.
"Our transatlantic flights have shown the huge demand for affordable long-haul travel, so we are delighted to expand into new markets and offer our first route to Asia from the UK," says Norwegian CEO Bjorn Kjos.
"The UK is at the heart of Norwegian's ambitious plans for growth so it is a significant moment not only to launch this exciting new route, but also for it to be the first long-haul route to take to the skies with our new 'Norwegian UK' subsidiary."
FlightGlobal schedules show that Norwegian will compete with Singapore Airlines, British Airways and Garuda Indonesia between Singapore and London.