TAP Portugal will terminate services to London City airport from Lisbon and Porto at the end of October.
The airline blames the move on uncertainties in demand associated with Brexit and lower than expected results on the routes, it says.
However, the lost seats will be partially offset in peak seasons by allocating larger aircraft on TAP’s services to Heathrow and Gatwick.
TAP launched flights to London City from Lisbon in 2017 and from Porto in 2018, using 100-seat Embraer 190 aircraft. London City to Lisbon currently operates with 12 TAP flights per week, against six on the route to Porto.
London City airport says it is "disappointed" that TAP was taking the action, but that is a consequence of overcapacity on the two routes.
The airport adds: "Route churn is an industry reality, but we hope we may see TAP back at London City in the future, as their services were valued by many. In the meantime we’ll focus on re-distributing these sought-after slots with new and existing airlines."